This is one of the most frequently used tools in bioinformantics, people used DAVID a lot, however few people realized DAVID stands on a soft ground as it soly relies on KEGG. KEGG has many limitations, including,
incompatible data formats, inconsistent molecular representations,
inconsistent molecular relationship representations, inconsistent
referrals to pathway names, and incomprehensive data from different
databases. Dr.
Zhou overcome
these issues through extraction, normalization and integration of
pathway data from several major public databases (KEGG, WikiPathways,
BioCyc, etc) and he build a database called
IntPath
to hosts the integrated pathway data for convenient public access.
Please visit IntPath: http://compbio.ddns.comp.nus.edu.sg:8080/IntPath/ and you will be amazed by how comprehensive the enrichment analysis can be.
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